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The diabetic β-cell: hyperstimulated vs. hyperexcited

Hyperglycaemia has multiple effects on β-cells, some clearly prosecretory, including hyperplasia and elevated insulin content, but eventually, a ‘glucotoxic’ effect which leads to pancreatic β-cell dysfunction, reduced β-cell mass and insulin deficiency, is an important part of diabetes pathophysiol...

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Detalhes bibliográficos
Main Authors: Nichols, C. G., Remedi, M. S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712635/
https://ncbi.nlm.nih.gov/pubmed/22928573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1463-1326.2012.01655.x
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