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The role of membrane excitability in pancreatic β-cell glucotoxicity
Persistent hyperglycemia is causally associated with pancreatic β-cell dysfunction and loss of pancreatic insulin. Glucose normally enhances β-cell excitability through inhibition of K(ATP) channels, opening of voltage-dependent calcium channels, increased [Ca(2+)](i), which triggers insulin secreti...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6502887/ https://ncbi.nlm.nih.gov/pubmed/31061431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43452-8 |
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