Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with complex etiology but strong clustering in families (λ(S) = ~30). We performed a genome-wide association scan using 317,501 SNPs in 720 women of European ancestry with SLE and in 2,337 controls, and we genotyped consisten...

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Autori principali: Harley, John B, Alarcón-Riquelme, Marta E, Criswell, Lindsey A, Jacob, Chaim O, Kimberly, Robert P, Moser, Kathy L, Tsao, Betty P, Vyse, Timothy J, Langefeld, Carl D, Nath, Swapan K, Guthridge, Joel M, Cobb, Beth L, Mirel, Daniel B, Marion, Miranda C, Williams, Adrienne H, Divers, Jasmin, Wang, Wei, Frank, Summer G, Namjou, Bahram, Gabriel, Stacey B, Lee, Annette T, Gregersen, Peter K, Behrens, Timothy W, Taylor, Kimberly E, Fernando, Michelle, Zidovetzki, Raphael, Gaffney, Patrick M, Edberg, Jeffrey C, Rioux, John D, Ojwang, Joshua O, James, Judith A, Merrill, Joan T, Gilkeson, Gary S, Seldin, Michael F, Yin, Hong, Baechler, Emily C, Li, Quan-Zhen, Wakeland, Edward K, Bruner, Gail R, Kaufman, Kenneth M, Kelly, Jennifer A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712260/
https://ncbi.nlm.nih.gov/pubmed/18204446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.81
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