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Multiple Lupus Associated ITGAM Variants Alter Mac-1 Function on Neutrophils
OBJECTIVE: Multiple studies have demonstrated that single-nucleotide polymorphisms (SNPs) in the ITGAM locus (including the non-synonymous SNPs rs1143679, rs1143678, rs1143683) are associated with SLE. ITGAM encodes the protein CD11b, a subunit of the β(2) integrin Mac-1. The purpose of this study w...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3969028/ https://ncbi.nlm.nih.gov/pubmed/23918739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38117 |
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