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PurBayes: estimating tumor cellularity and subclonality in next-generation sequencing data
Summary: We have developed a novel Bayesian method, PurBayes, to estimate tumor purity and detect intratumor heterogeneity based on next-generation sequencing data of paired tumor-normal tissue samples, which uses finite mixture modeling methods. We demonstrate our approach using simulated data and...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3712213/ https://ncbi.nlm.nih.gov/pubmed/23749958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btt293 |
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