Generation of minipigs with targeted transgene insertion by recombinase-mediated cassette exchange (RMCE) and somatic cell nuclear transfer (SCNT)

Targeted transgenesis using site-specific recombinases is an attractive method to create genetically modified animals as it allows for integration of the transgene in a pre-selected transcriptionally active genomic site. Here we describe the application of recombinase-mediated cassette exchange (RMC...

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Détails bibliographiques
Auteurs principaux: Jakobsen, Jannik Ejnar, Johansen, Marianne G., Schmidt, Mette, Dagnæs-Hansen, Frederik, Dam, Karen, Gunnarsson, Anders, Liu, Ying, Kragh, Peter M., Li, Rong, Holm, Ida E., Callesen, Henrik, Mikkelsen, Jacob Giehm, Nielsen, Anders Lade, Jørgensen, Arne Lund
Format: Artigo
Langue:Inglês
Publié: Springer Netherlands 2012
Sujets:
Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712138/
https://ncbi.nlm.nih.gov/pubmed/23111619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11248-012-9671-6
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