The CRISPR/Cas9 Minipig—A Transgenic Minipig to Produce Specific Mutations in Designated Tissues

SIMPLE SUMMARY: Research in large animal models has been hampered by the complexity to introduce new gene alterations, but this has been simplified by the discovery of the CRISPR/Cas system. Here, we have cloned a Cas9 minipig to generate a porcine model for pre-clinical research. Six viable piglets...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Berthelsen, Martin Fogtmann, Riedel, Maria, Cai, Huiqiang, Skaarup, Søren H., Alstrup, Aage K. O., Dagnæs-Hansen, Frederik, Luo, Yonglun, Jensen, Uffe B., Hager, Henrik, Liu, Ying, Callesen, Henrik, Vendelbo, Mikkel H., Jakobsen, Jannik E., Thomsen, Martin Kristian
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8234985/
https://ncbi.nlm.nih.gov/pubmed/34208747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13123024
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