X-Box Binding Protein 1 Is Essential for Insulin Regulation of Pancreatic α-Cell Function

Patients with type 2 diabetes (T2D) often exhibit hyperglucagonemia despite hyperglycemia, implicating defective α-cell function. Although endoplasmic reticulum (ER) stress has been suggested to underlie β-cell dysfunction in T2D, its role in α-cell biology remains unclear. X-box binding protein 1 (...

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Bibliographic Details
Main Authors: Akiyama, Masaru, Liew, Chong Wee, Lu, Shusheng, Hu, Jiang, Martinez, Rachael, Hambro, Ben, Kennedy, Robert T., Kulkarni, Rohit N.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2013
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712068/
https://ncbi.nlm.nih.gov/pubmed/23493568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1747
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