Munc18b Is a Major Mediator of Insulin Exocytosis in Rat Pancreatic β-Cells

Sec1/Munc18 proteins facilitate the formation of trans-SNARE (soluble N-ethylmaleimide–sensitive factor attachment protein receptor) complexes that mediate fusion of secretory granule (SG) with plasma membrane (PM). The capacity of pancreatic β-cells to exocytose insulin becomes compromised in diabe...

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Autores principales: Lam, Patrick P.L., Ohno, Mitsuyo, Dolai, Subhankar, He, Yu, Qin, Tairan, Liang, Tao, Zhu, Dan, Kang, Youhou, Liu, Yunfeng, Kauppi, Maria, Xie, Li, Wan, Wilson C.Y., Bin, Na-Rhum, Sugita, Shuzo, Olkkonen, Vesa M., Takahashi, Noriko, Kasai, Haruo, Gaisano, Herbert Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712044/
https://ncbi.nlm.nih.gov/pubmed/23423569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1380
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