Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth

BACKGROUND: Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor kinase that plays a major role in cancer cell survival and metastasis. METHODS: We performed computer modeling of the p53 peptide containing the site of interaction with FAK, predicted the peptide structure and docked it into the thre...

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Detaylı Bibliyografya
Asıl Yazarlar: Golubovskaya, Vita M, Ho, Baotran, Zheng, Min, Magis, Andrew, Ostrov, David, Morrison, Carl, Cance, William G
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712010/
https://ncbi.nlm.nih.gov/pubmed/23841915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-342
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