Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth

BACKGROUND: Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor kinase that plays a major role in cancer cell survival and metastasis. METHODS: We performed computer modeling of the p53 peptide containing the site of interaction with FAK, predicted the peptide structure and docked it into the thre...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Golubovskaya, Vita M, Ho, Baotran, Zheng, Min, Magis, Andrew, Ostrov, David, Morrison, Carl, Cance, William G
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712010/
https://ncbi.nlm.nih.gov/pubmed/23841915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-342
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky