Glutamatergic Dysbalance and Oxidative Stress in In Vivo and In Vitro Models of Psychosis Based on Chronic NMDA Receptor Antagonism

BACKGROUND: The psychotomimetic effects of N-methyl-D-aspartate (NMDA) receptor antagonists in healthy humans and their tendency to aggravate psychotic symptoms in schizophrenic patients have promoted the notion of altered glutamatergic neurotransmission in the pathogenesis of schizophrenia. METHODS...

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Main Authors: Genius, Just, Geiger, Johanna, Dölzer, Anna-Lena, Benninghoff, Jens, Giegling, Ina, Hartmann, Annette M., Möller, Hans-Jürgen, Rujescu, Dan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711936/
https://ncbi.nlm.nih.gov/pubmed/23869202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059395
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