Glutamatergic Dysbalance and Oxidative Stress in In Vivo and In Vitro Models of Psychosis Based on Chronic NMDA Receptor Antagonism

BACKGROUND: The psychotomimetic effects of N-methyl-D-aspartate (NMDA) receptor antagonists in healthy humans and their tendency to aggravate psychotic symptoms in schizophrenic patients have promoted the notion of altered glutamatergic neurotransmission in the pathogenesis of schizophrenia. METHODS...

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Main Authors: Genius, Just, Geiger, Johanna, Dölzer, Anna-Lena, Benninghoff, Jens, Giegling, Ina, Hartmann, Annette M., Möller, Hans-Jürgen, Rujescu, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711936/
https://ncbi.nlm.nih.gov/pubmed/23869202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059395
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