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Blockade of cytotoxic T-lymphocyte antigen-4 as a novel therapeutic approach for advanced melanoma
INTRODUCTION: The incidence of melanoma continues to rise and prognosis in patients with metastatic melanoma remains poor. The cytotoxic T-lymphocyte antigen-4 (CTLA-4) serves as one of the primary immune checkpoints and downregulates T cell activation pathways. Enhancing T cell activation by antibo...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711751/ https://ncbi.nlm.nih.gov/pubmed/22077831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/14656566.2011.629187 |
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