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INFLUENCE OF CYTOTOXIC T LYMPHOCYTE-ASSOCIATED ANTIGEN 4 (CTLA4) COMMON POLYMORPHISMS ON OUTCOME IN TREATMENT OF MELANOMA PATIENTS WITH CTLA-4 BLOCKADE
Blockade of the Cytotoxic T Lymphocyte-associated Antigen 4 (CTLA-4), a down-regulator of T cell activation, can cause cancer regression in patients with metastatic melanoma. However, not all patients respond well to the therapy and some develop severe autoimmune reactions. We hypothesized that comm...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3276400/ https://ncbi.nlm.nih.gov/pubmed/18528295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e31817fd8f3 |
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