INFLUENCE OF CYTOTOXIC T LYMPHOCYTE-ASSOCIATED ANTIGEN 4 (CTLA4) COMMON POLYMORPHISMS ON OUTCOME IN TREATMENT OF MELANOMA PATIENTS WITH CTLA-4 BLOCKADE

Blockade of the Cytotoxic T Lymphocyte-associated Antigen 4 (CTLA-4), a down-regulator of T cell activation, can cause cancer regression in patients with metastatic melanoma. However, not all patients respond well to the therapy and some develop severe autoimmune reactions. We hypothesized that comm...

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Main Authors: Breunis, Willemijn B, Tarazona-Santos, Eduardo, Chen, Renee, Kiley, Maureen, Rosenberg, Steven A, Chanock, Stephen J
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276400/
https://ncbi.nlm.nih.gov/pubmed/18528295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e31817fd8f3
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