Enhancing Mitochondrial Calcium Buffering Capacity Reduces Aggregation of Misfolded SOD1 and Motor Neuron Cell Death without Extending Survival in Mouse Models of Inherited Amyotrophic Lateral Sclerosis

Mitochondria have been proposed as targets for toxicity in amyotrophic lateral sclerosis (ALS), a progressive, fatal adult-onset neurodegenerative disorder characterized by the selective loss of motor neurons. A decrease in the capacity of spinal cord mitochondria to buffer calcium (Ca(2+)) has been...

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Main Authors: Parone, Philippe A., Da Cruz, Sandrine, Han, Joo Seok, McAlonis-Downes, Melissa, Vetto, Anne P., Lee, Sandra K., Tseng, Eva, Cleveland, Don W.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711648/
https://ncbi.nlm.nih.gov/pubmed/23486940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1119-12.2013
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