Pancreatic beta cell mass PET imaging and quantification with [(11)C]DTBZ and [(18)F]FP-(+)-DTBZ in rodent models of diabetes

PURPOSE: The aim of this study is to compare the utility of two PET imaging ligands ((+)-[(11)C]dihydrotetrabenazine ([(11)C]DTBZ) and the fluoropropyl analogue ([(18)F]FP-(+)-DTBZ)) that target islet β-cell vesicular monoamine transporter type II (VMAT2) to measure pancreatic β-cell mass (BCM). PRO...

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Detalhes bibliográficos
Main Authors: Singhal, Tarun, Ding, Yu-Shin, Weinzimmer, David, Normandin, Marc D., Labaree, David, Ropchan, Jim, Nabulsi, Nabeel, Lin, Shu-fei, Skaddan, Marc B., Soeller, Walter C., Huang, Yiyun, Carson, Richard E., Treadway, Judith L., Cline, Gary W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711476/
https://ncbi.nlm.nih.gov/pubmed/20824509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-010-0406-x
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