Glycoprotein Biosynthesis in a Eukaryote Lacking the Membrane Protein Rft1

Mature dolichol-linked oligosaccharides (mDLOs) needed for eukaryotic protein N-glycosylation are synthesized by a multistep pathway in which the biosynthetic lipid intermediate Man(5)GlcNAc(2)-PP-dolichol (M5-DLO) flips from the cytoplasmic to the luminal face of the endoplasmic reticulum. The endo...

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Bibliographic Details
Main Authors: Jelk, Jennifer, Gao, Ningguo, Serricchio, Mauro, Signorell, Aita, Schmidt, Remo S., Bangs, James D., Acosta-Serrano, Alvaro, Lehrman, Mark A., Bütikofer, Peter, Menon, Anant K.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711325/
https://ncbi.nlm.nih.gov/pubmed/23720757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.479642
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