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The Metabolic Origins of Mannose in Glycoproteins

Mannose in N-glycans is derived from glucose through phosphomannose isomerase (MPI, Fru-6-P ↔ Man-6-P) whose deficiency causes a congenital disorder of glycosylation (CDG)-Ib (MPI-CDG). Mannose supplements improve patients' symptoms because exogenous mannose can also directly contribute to N-gl...

詳細記述

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書誌詳細
主要な著者: Ichikawa, Mie, Scott, David A., Losfeld, Marie-Estelle, Freeze, Hudson H.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945336/
https://ncbi.nlm.nih.gov/pubmed/24407290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.544064
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