A potent and selective small molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases

Lymphoid-specific tyrosine phosphatase (LYP), a member of the protein tyrosine phosphatase (PTP) family of signaling enzymes, is associated with a broad spectrum of autoimmune diseases. Herein we describe our structure-based lead optimization efforts within a 6-hydroxy-benzofuran-5-carboxylic acid s...

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Detalhes bibliográficos
Main Authors: He, Yantao, Liu, Sijiu, Menon, Ambili, Stanford, Stephanie, Oppong, Emmanuel, Gunawan, Andrea M., Wu, Li, Wu, Dennis J., Barrios, Amy M., Bottini, Nunzio, Cato, Andrew C. B., Zhang, Zhong-Yin
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711248/
https://ncbi.nlm.nih.gov/pubmed/23713581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400248c
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