Palm Mutants in DNA Polymerases α and η Alter DNA Replication Fidelity and Translesion Activity

We isolated active mutants in Saccharomyces cerevisiae DNA polymerase α that were associated with a defect in error discrimination. Among them, L868F DNA polymerase α has a spontaneous error frequency of 3 in 100 nucleotides and 570-fold lower replication fidelity than wild-type (WT) polymerase α. I...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Niimi, Atsuko, Limsirichaikul, Siripan, Yoshida, Shonen, Iwai, Shigenori, Masutani, Chikahide, Hanaoka, Fumio, Kool, Eric T., Nishiyama, Yukihiro, Suzuki, Motoshi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2004
Schlagworte:	DNA Dynamics and Chromosome Structure
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC371111/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15024063/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.7.2734-2746.2004
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