Palm Mutants in DNA Polymerases α and η Alter DNA Replication Fidelity and Translesion Activity

We isolated active mutants in Saccharomyces cerevisiae DNA polymerase α that were associated with a defect in error discrimination. Among them, L868F DNA polymerase α has a spontaneous error frequency of 3 in 100 nucleotides and 570-fold lower replication fidelity than wild-type (WT) polymerase α. I...

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Detalhes bibliográficos
Main Authors: Niimi, Atsuko, Limsirichaikul, Siripan, Yoshida, Shonen, Iwai, Shigenori, Masutani, Chikahide, Hanaoka, Fumio, Kool, Eric T., Nishiyama, Yukihiro, Suzuki, Motoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC371111/
https://ncbi.nlm.nih.gov/pubmed/15024063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.7.2734-2746.2004
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