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Palm Mutants in DNA Polymerases α and η Alter DNA Replication Fidelity and Translesion Activity
We isolated active mutants in Saccharomyces cerevisiae DNA polymerase α that were associated with a defect in error discrimination. Among them, L868F DNA polymerase α has a spontaneous error frequency of 3 in 100 nucleotides and 570-fold lower replication fidelity than wild-type (WT) polymerase α. I...
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| Hoofdauteurs: | , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Microbiology
2004
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC371111/ https://ncbi.nlm.nih.gov/pubmed/15024063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.7.2734-2746.2004 |
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