Predisposition to apoptosis in keratin 8-null liver is related to inactivation of NF-κB and SAPKs but not decreased c-Flip

Keratin 8 and 18 (K8/K18) are major intermediate filament proteins of liver hepatocytes. They provide mechanical and nonmechanical stability, thereby protecting cells from stress. Hence, K8-null mice are highly sensitive to Fas-mediated liver cell apoptosis. However, the role of c-Flip protein in K8...

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Detalhes bibliográficos
Main Authors: Lee, Jongeun, Jang, Kwi-Hoon, Kim, Hakhyun, Lim, Younglan, Kim, Sujin, Yoon, Han-Na, Chung, In Kwon, Roth, Jürgen, Ku, Nam-On
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711037/
https://ncbi.nlm.nih.gov/pubmed/23862017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20134606
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