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Small Molecule-Mediated Cleavage of RNA in Living Cells
Antisense oligonucleotides and small interfering RNAs (siRNAs) control gene expression by triggering the degradation of a mRNA via recruitment of RNase H or the RNA-induced silencing complex (RISC), respectively.([1]) These approaches are hampered, however, by the poor cellular permeability of oligo...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711026/ https://ncbi.nlm.nih.gov/pubmed/23280953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201206888 |
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