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Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad

Caseinolytic proteases (ClpPs) are large oligomeric protein complexes that contribute to cell homeostasis as well as virulence regulation in bacteria. Although most organisms possess a single ClpP protein, some organisms encode two or more ClpP isoforms. Here, we elucidated the crystal structures of...

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Detalhes bibliográficos
Main Authors: Zeiler, Evelyn, List, Anja, Alte, Ferdinand, Gersch, Malte, Wachtel, Rudolf, Poreba, Marcin, Drag, Marcin, Groll, Michael, Sieber, Stephan A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710848/
https://ncbi.nlm.nih.gov/pubmed/23798410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219125110
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