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Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors

The genetic and biophysical mechanisms by which new protein functions evolve is a central question in evolutionary biology, biochemistry, and biophysics. Of particular interest is whether major shifts in protein function are caused by a few mutations of large effect and, if they are, the mechanisms...

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Bibliografiske detaljer
Main Authors: Harms, Michael J., Eick, Geeta N., Goswami, Devrishi, Colucci, Jennifer K., Griffin, Patrick R., Ortlund, Eric A., Thornton, Joseph W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710831/
https://ncbi.nlm.nih.gov/pubmed/23798447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303930110
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