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Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors

Most proteins are regulated by physical interactions with other molecules; some are highly specific, but others interact with many partners. Despite much speculation, we know little about how and why specificity/promiscuity evolves in natural proteins. It is widely assumed that specific proteins evo...

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Main Authors: Eick, Geeta N., Colucci, Jennifer K., Harms, Michael J., Ortlund, Eric A., Thornton, Joseph W.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499368/
https://ncbi.nlm.nih.gov/pubmed/23166518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003072
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