Molecular basis for chromatin binding and regulation of MLL5

The human mixed-lineage leukemia 5 (MLL5) protein mediates hematopoietic cell homeostasis, cell cycle, and survival; however, the molecular basis underlying MLL5 activities remains unknown. Here, we show that MLL5 is recruited to gene-rich euchromatic regions via the interaction of its plant homeodo...

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Autors principals: Ali, Muzaffar, Rincón-Arano, Héctor, Zhao, Wei, Rothbart, Scott B., Tong, Qiong, Parkhurst, Susan M., Strahl, Brian D., Deng, Lih-Wen, Groudine, Mark, Kutateladze, Tatiana G.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710826/
https://ncbi.nlm.nih.gov/pubmed/23798402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310156110
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