Long Runs of Homozygosity Are Enriched for Deleterious Variation

Exome sequencing offers the potential to study the population-genomic variables that underlie patterns of deleterious variation. Runs of homozygosity (ROH) are long stretches of consecutive homozygous genotypes probably reflecting segments shared identically by descent as the result of processes suc...

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Main Authors: Szpiech, Zachary A., Xu, Jishu, Pemberton, Trevor J., Peng, Weiping, Zöllner, Sebastian, Rosenberg, Noah A., Li, Jun Z.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710769/
https://ncbi.nlm.nih.gov/pubmed/23746547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2013.05.003
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