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The plasma membrane transporter SLC5A8 suppresses tumor progression through depletion of survivin without involving its transport function
SLC5A8 is a sodium-coupled transporter for monocarboxylates. Among its substrates are the HDAC inhibitors butyrate, propionate, and pyruvate. Expression of SLC5A8 is silenced in cancers via DNA methylation, and ectopic expression of SLC5A8 in cancer cells induces apoptosis in the presence of its sub...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3710455/ https://ncbi.nlm.nih.gov/pubmed/23167260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20121248 |
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