SLC6A14 (ATB(0,+)) Protein, a Highly Concentrative and Broad Specific Amino Acid Transporter, Is a Novel and Effective Drug Target for Treatment of Estrogen Receptor-positive Breast Cancer

SLC6A14, also known as ATB(0,+), is an amino acid transporter with unique characteristics. It transports 18 of the 20 proteinogenic amino acids. However, this transporter is expressed only at low levels in normal tissues. Here, we show that the transporter is up-regulated specifically in estrogen re...

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Main Authors: Karunakaran, Senthil, Ramachandran, Sabarish, Coothankandaswamy, Veena, Elangovan, Selvakumar, Babu, Ellappan, Periyasamy-Thandavan, Sudharsan, Gurav, Ashish, Gnanaprakasam, Jaya P., Singh, Nagendra, Schoenlein, Patricia V., Prasad, Puttur D., Thangaraju, Muthusamy, Ganapathy, Vadivel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173074/
https://ncbi.nlm.nih.gov/pubmed/21771784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.229518
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