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Valproic acid shows potent antitumor effect with alteration of DNA methylation in neuroblastoma
Epigenetic aberrations and a CpG island methylator phenotype are associated with poor outcome in children with neuroblastoma (NB). Previously, we demonstrated that valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, has antitumor effects in an NB xenograft model. However, the underlying ant...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3710400/ https://ncbi.nlm.nih.gov/pubmed/22863973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CAD.0b013e32835739dd |
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