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Valproic acid shows potent antitumor effect with alteration of DNA methylation in neuroblastoma
Epigenetic aberrations and a CpG island methylator phenotype are associated with poor outcome in children with neuroblastoma (NB). Previously, we demonstrated that valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, has antitumor effects in an NB xenograft model. However, the underlying ant...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3710400/ https://ncbi.nlm.nih.gov/pubmed/22863973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CAD.0b013e32835739dd |
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