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Interaction of local anesthetics with the K(+) channel pore domain: KcsA as a model for drug-dependent tetramer stability
Local anesthetics and related drugs block ionic currents of Na(+), K(+) and Ca(2+) conducted across the cell membrane by voltage-dependent ion channels. Many of these drugs bind in the permeation pathway, occlude the pore and stop ion movement. However channel-blocking drugs have also been associate...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3710345/ https://ncbi.nlm.nih.gov/pubmed/23545989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.24455 |
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