Oral Administration of a Small Molecule Targeted to Block proNGF Binding to p75 Promotes Myelin Sparing and Functional Recovery after Spinal Cord Injury

The lack of effective therapies for spinal cord injury points to the need for identifying novel targets for therapeutic intervention. Here we report that a small molecule, LM11A-31, developed to block proNGF-p75 interaction and p75-mediated cell death crosses the blood–brain barrier efficiently when...

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Main Authors: Tep, Chhavy, Lim, Tae Hee, Ko, Pyung On, Getahun, Sami, Ryu, Jae Cheon, Goettl, Virginia M., Massa, Stephen M., Basso, Michele, Longo, Frank M., Yoon, Sung Ok
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710149/
https://ncbi.nlm.nih.gov/pubmed/23303920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0399-12.2013
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