Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer

Notch1 is a rational therapeutic target in several human cancers, but as a transcriptional regulator, it poses a drug discovery challenge. To identify Notch1 modulators, we performed two cell-based, high-throughput screens for small-molecule inhibitors and cDNA enhancers of a NOTCH1 allele bearing a...

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Detalhes bibliográficos
Main Authors: Roti, Giovanni, Carlton, Anne, Ross, Kenneth N., Markstein, Michele, Pajcini, Kostandin, Su, Angela H., Perrimon, Norbert, Pear, Warren S., Kung, Andrew L., Blacklow, Stephen C., Aster, Jon C., Stegmaier, Kimberly
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709972/
https://ncbi.nlm.nih.gov/pubmed/23434461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.01.015
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