Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding

MICA and MICB (MHC-class-I-related chain A/B) are transmembrane proteins expressed in pathological conditions that are ligands for NKG2D, an activating receptor found on cytotoxic lymphocytes. The recognition on target cells of NKG2D ligands leads to the activation of lysis and cytokine secretion by...

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Main Authors: Agüera-González, Sonia, Gross, Catharina C., Fernández-Messina, Lola, Ashiru, Omodele, Esteso, Gloria, Hang, Howard C., Reyburn, Hugh T., Long, Eric O., Valés-Gómez, Mar
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709245/
https://ncbi.nlm.nih.gov/pubmed/21928280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201141645
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