The Conserved Intronic Cleavage and Polyadenylation Site of CstF-77 Gene Imparts Control of 3′ End Processing Activity through Feedback Autoregulation and by U1 snRNP

The human gene encoding the cleavage/polyadenylation (C/P) factor CstF-77 contains 21 exons. However, intron 3 (In3) accounts for nearly half of the gene region, and contains a C/P site (pA) with medium strength, leading to short mRNA isoforms with no apparent protein products. This intron contains...

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Autores principales: Luo, Wenting, Ji, Zhe, Pan, Zhenhua, You, Bei, Hoque, Mainul, Li, Wencheng, Gunderson, Samuel I., Tian, Bin
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708835/
https://ncbi.nlm.nih.gov/pubmed/23874216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003613
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