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Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice

BACKGROUND: Glaucoma is an age-related neurodegenerative disorder involving the loss of retinal ganglion cells (RGCs), which results in blindness. Studies in animal models have shown that activation of inflammatory processes occurs early in the disease. In particular, the complement cascade is activ...

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Bibliographische Detailangaben
Hauptverfasser: Howell, Gareth R, Soto, Ileana, Ryan, Margaret, Graham, Leah C, Smith, Richard S, John, Simon WM
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708765/
https://ncbi.nlm.nih.gov/pubmed/23806181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-10-76
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