Cap-dependent mRNA translation and the ubiquitin-proteasome system cooperate to promote ERBB2-dependent esophageal cancer phenotype

Pathological post-transcriptional control of the proteome composition is a central feature of malignancy. Two steps in this pathway, eIF4F-driven cap-dependent mRNA translation and the ubiquitin-proteasome system (UPS), are deregulated in most if not all cancers. We tested a hypothesis that eIF4F is...

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Detaylı Bibliyografya
Asıl Yazarlar: Issaenko, OA, Bitterman, PB, Polunovsky, VA, Dahlberg, PS
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708616/
https://ncbi.nlm.nih.gov/pubmed/22767218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2012.39
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