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Analysis of Vif-induced APOBEC3G Degradation Using an α-Complementation Assay
Vif forms a complex with Elongin B/C, Cullin-5 and Rbx-1 to induce the polyubiquitination and proteasome-mediated degradation of human APOBEC3G (hA3G). These interactions serve as potential targets for anti-HIV-1 drug development. We have developed a cell culture-based assay to measure Vif-induced A...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3708489/ https://ncbi.nlm.nih.gov/pubmed/17049578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2006.09.013 |
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