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Mechanisms of T-cell protection from death by IRX-2: a new immunotherapeutic

OBJECTIVES: IRX-2 is a novel immunotherapeutic containing physiologic quantities of several cytokines which protects human T lymphocytes from tumor-induced or drug-induced apoptosis. Here, we investigate the mechanisms responsible for IRX-2-mediated protection of T lymphocytes exposed to tumor-deriv...

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Main Authors: Czystowska, Malgorzata, Szczepanski, Miroslaw J., Szajnik, Marta, Quadrini, Karen, Brandwein, Harvey, Hadden, John W., Whiteside, Theresa L.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708464/
https://ncbi.nlm.nih.gov/pubmed/21181158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-010-0951-9
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