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Fibroblast Growth Factor Receptor 3 is a Rational Therapeutic Target in Bladder Cancer

Activating mutations of Fibroblast growth factor receptor-3 (FGFR3) have been described in approximately 75% of low-grade papillary bladder tumors. In muscle invasive disease, FGFR3 mutations are found in 20% of tumors, but overexpression of FGFR3 is observed in about half of cases. Therefore, FGFR3...

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Detalhes bibliográficos
Main Authors: Gust, Kilian M., McConkey, David J., Awrey, Shannon, Hegarty, Paul K., Qing, Jing, Bondaruk, Jolanta, Ashkenazi, Avi, Czerniak, Bogdan, Dinney, Colin P., Black, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707970/
https://ncbi.nlm.nih.gov/pubmed/23657946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-1150
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