Prefoldin Protects Neuronal Cells from Polyglutamine Toxicity by Preventing Aggregation Formation

Huntington disease is caused by cell death after the expansion of polyglutamine (polyQ) tracts longer than ∼40 repeats encoded by exon 1 of the huntingtin (HTT) gene. Prefoldin is a molecular chaperone composed of six subunits, PFD1–6, and prevents misfolding of newly synthesized nascent polypeptide...

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Main Authors: Tashiro, Erika, Zako, Tamotsu, Muto, Hideki, Itoo, Yoshinori, Sörgjerd, Karin, Terada, Naofumi, Abe, Akira, Miyazawa, Makoto, Kitamura, Akira, Kitaura, Hirotake, Kubota, Hiroshi, Maeda, Mizuo, Momoi, Takashi, Iguchi-Ariga, Sanae M. M., Kinjo, Masataka, Ariga, Hiroyoshi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707696/
https://ncbi.nlm.nih.gov/pubmed/23720755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.477984
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