The Lectin Domain of the Polypeptide GalNAc Transferase Family of Glycosyltransferases (ppGalNAc Ts) Acts as a Switch Directing Glycopeptide Substrate Glycosylation in an N- or C-terminal Direction, Further Controlling Mucin Type O-Glycosylation

Mucin type O-glycosylation is initiated by a large family of polypeptide GalNAc transferases (ppGalNAc Ts) that add α-GalNAc to the Ser and Thr residues of peptides. Of the 20 human isoforms, all but one are composed of two globular domains linked by a short flexible linker: a catalytic domain and a...

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Hlavní autoři: Gerken, Thomas A., Revoredo, Leslie, Thome, Joseph J. C., Tabak, Lawrence A., Vester-Christensen, Malene Bech, Clausen, Henrik, Gahlay, Gagandeep K., Jarvis, Donald L., Johnson, Roy W., Moniz, Heather A., Moremen, Kelley
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707691/
https://ncbi.nlm.nih.gov/pubmed/23689369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.477877
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