Identification of DNMT1 Selective Antagonists Using a Novel Scintillation Proximity Assay

A novel scintillation proximity high throughput assay (SPA) to identify inhibitors of DNA methyltransferases was developed and used to screen over 180,000 compounds. The majority of the validated hits shared a quinone core and several were found to generate the reactive oxygen species, H(2)O(2). Inh...

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Autores principales: Kilgore, Jessica A., Du, Xinlin, Melito, Lisa, Wei, Shuguang, Wang, Changguang, Chin, Hang Gyeong, Posner, Bruce, Pradhan, Sriharsa, Ready, Joseph M., Williams, Noelle S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707673/
https://ncbi.nlm.nih.gov/pubmed/23671287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.443895
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