CD44 Is the Signaling Component of the Macrophage Migration Inhibitory Factor-CD74 Receptor Complex

The macrophage migration inhibitory factor (MIF) receptor (CD74) was cloned recently, but the signaling mechanism is not evident. We hypothesized that signaling requires an additional molecule such as CD44, which activates nonreceptor tyrosine kinases. We utilized the CD74- and CD44-deficient COS-7/...

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Hauptverfasser: Shi, Xuerong, Leng, Lin, Wang, Tian, Wang, Wenkui, Du, Xin, Li, Ji, McDonald, Courtney, Chen, Zun, Murphy, James W., Lolis, Elias, Noble, Paul, Knudson, Warren, Bucala, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707630/
https://ncbi.nlm.nih.gov/pubmed/17045821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2006.08.020
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