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CCR2 Deficiency, Dysregulation of Notch Signaling, and Spontaneous Pulmonary Arterial Hypertension
In pulmonary arterial hypertension (PAH), there is overexpression of the chemokine, C-C chemokine ligand type 2 (CCL2), and infiltration of myeloid cells into the pulmonary vasculature. Inhibition of CCL2 in animals decreases PAH, suggesting that the CCL2 receptor (CCR2) plays a role in PAH developm...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Thoracic Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3707377/ https://ncbi.nlm.nih.gov/pubmed/23492191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0182OC |
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