Effect of Zileuton and Celecoxib on Urinary LTE(4) and PGE-M Levels in Smokers

Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) utilize arachidonic acid for the synthesis of eicosanoids that have been implicated in carcinogenesis and cardiovascular disease. The ability of celecoxib, a selective COX-2 inhibitor, to redirect arachidonic acid into the 5-LO pathway can potential...

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Autors principals: Mohebati, Arash, Milne, Ginger L., Zhou, Xi Kathy, Duffield-Lillico, Anna J., Boyle, Jay O., Knutson, Allison, Bosworth, Brian P., Kingsley, Philip J., Marnett, Lawrence J., Brown, Powel H., Akpa, Esther G., Szabo, Eva, Dannenberg, Andrew J.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707304/
https://ncbi.nlm.nih.gov/pubmed/23682075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-13-0083
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