Cox-2-derived PGE(2) induces Id1-dependent radiation resistance and self-renewal in experimental glioblastoma

BACKGROUND: In glioblastoma (GBM), Id1 serves as a functional marker for self-renewing cancer stem-like cells. We investigated the mechanism by which cyclooxygenase-2 (Cox-2)-derived prostaglandin E(2) (PGE(2)) induces Id1 and increases GBM self-renewal and radiation resistance. METHODS: Mouse and h...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Cook, Peter J., Thomas, Rozario, Kingsley, Philip J., Shimizu, Fumiko, Montrose, David C., Marnett, Lawrence J., Tabar, Viviane S., Dannenberg, Andrew J., Benezra, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Basic and Translational Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035519/
https://ncbi.nlm.nih.gov/pubmed/27022132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now049
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